Is alcohol consumption a risk factor for prostate cancer? A systematic review and meta–analysis

BMC Cancer

Table 3 Adjusted mean RR estimates of prostate cancer morbidity or mortality for different categories of drinkers compared with abstainers (N = 27 studies and 126 risk estimates)

Drinking categories	N/n^a	Weighted Mean RR^b			Partially adjusted mean RR^c			Fully adjusted mean RR^d
Drinking categories	N/n^a	RR & 95 % CI		t–test P	RR & 95 % CI		t–test P	RR & 95 % CI		t–test P
Abstainer		1.00			1.00			1.00
Former drinker	7/13	1.14	0.99 – 1.30	0.0642	1.12	0.98 – 1.29	0.0990	1.10	0.97 – 1.25	0.1348
Occasional (<1.30 g/day)	6/7	0.97	0.86 – 1.10	0.6126	0.96	0.85 – 1.08	0.5265	0.95	0.85 – 1.06	0.3263
Low volume (1.30– < 25 g/day)	27/62	1.07	1.04 – 1.10	0.0001	1.08	1.05 – 1.12	0.0001	1.08	1.04 – 1.11	0.0001
Medium volume (25– < 45 g/day)	18/20	1.06	1.02 – 1.11	0.0068	1.08	1.03 – 1.13	0.0023	1.07	1.02 – 1.12	0.0041
High volume (45– < 65 g/day)	10/11	1.15	1.08 – 1.22	0.0001	1.17	1.09 – 1.25	0.0001	1.14	1.08 – 1.22	0.0001
Higher volume (65+ g/day)	9/13	1.18	1.09 – 1.27	0.0001	1.20	1.11 – 1.29	0.0001	1.18	1.10 – 1.27	0.0001
Any drinking	27/126	1.08	1.04 – 1.12	0.0039	1.10	1.02 – 1.18	0.0214	1.08	1.01 – 1.17	0.0364

Note: ^a N = Number of studies and n = Number of risk estimates. ^bWeighted using the inverse of variance of natural log–RR. ^cWeighted RR estimates adjusted for both former and occasional drinker biases. ^dWeighted RR estimates adjusted for between–study variation, both former and occasional drinker biases, US/non–US study and control for smoking status in individual studies

ISSN: 1471-2407